药物化学杂志 SCIESCI

期刊简介预计审稿时间：约2.1个月

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

Some specific areas that are appropriate include the following:

* Design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools.

* Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). Routine extensions of existing series that do not utilize novel chemical or biological approaches or do not add significantly to a basic understanding of the SAR of the series will normally not be accepted for publication.

*Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds.

* Molecular biological studies (e.g., site-directed mutagenesis) of macromolecular targets that lead to an improved understanding of molecular recognition.

*Computational studies that provide fresh insight into the SAR of compound series that are of current general interest or analysis of other available data that subsequently advance medicinal chemistry knowledge.

* Substantially novel computational chemistry methods with demonstrated value for the identification, optimization, or target interaction analysis of bioactive molecules.

* Effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation of biologically active compounds. This may include design, synthesis, and evaluation of novel types of prodrugs.

* Novel methodology with broad application to medicinal chemistry, but only if the methods have been tested on relevant molecules.

《药物化学杂志》发表的研究有助于理解分子结构与生物活性或作用方式之间的关系。

一些适合的具体领域包括：

* 用作药理学工具的新型生物活性化合物、诊断剂或标记配体的设计、合成和生物学评估。

* 报告系列的分子修饰，显着提高了对其构效关系 (SAR) 的理解。现有系列的常规扩展不使用新的化学或生物学方法，或不会显着增加对该系列的 SAR 的基本了解，通常不会被接受出版。

*相关配体和靶标的结构生物学研究（X 射线、NMR 等），旨在研究生物活性化合物作用中的分子识别过程。

* 大分子靶点的分子生物学研究（例如，定点诱变），有助于加深对分子识别的理解。

*计算研究提供对当前普遍感兴趣的化合物系列的 SAR 的新见解，或分析其他可用数据，从而提高药物化学知识。

* 实质上新颖的计算化学方法，在生物活性分子的识别、优化或目标相互作用分析方面具有证明价值。

* 分子结构对生物活性化合物的分布、药代动力学和代谢转化的影响。这可能包括新型前药的设计、合成和评估。

* 广泛应用于药物化学的新方法，但前提是这些方法已在相关分子上进行了测试。

《Journal Of Medicinal Chemistry》(药物化学杂志)编辑部通讯方式为AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036。如果您需要协助投稿或润稿服务，您可以咨询我们的客服老师。我们专注于期刊投稿服务十年，熟悉发表政策，可为您提供一对一投稿指导，避免您在投稿时频繁碰壁，节省您的宝贵时间，有效提升发表机率，确保SCI检索（检索不了全额退款）。我们视信誉为生命，多方面确保文章安全保密，在任何情况下都不会泄露您的个人信息或稿件内容。